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Similar content being viewed by others Introduction Wilms tumor (WT) is the most common childhood renal tumor and represents ~6% of all pediatric cancers with a peak age of presentation at 3 years 1,2,3

For example, inhibiting FASN can reduce the proliferation and survival of cancer cells, and FASN inhibitors have shown anti-tumor effects in preclinical models (Lupu and Menendez, 2006

Department of Radiology, Jinling Hospital, Medical School of Nanjing University 2Lawson Health Research Institute 2National Intrepid Center of Excellence, Walter Read National Military Medical Center 2nd Affiliated Hospital of Nanjing Medical University 2Siemens Healthcare GmbH 4

In agreement with the above, altered energy metabolism in the brain correlates with increased ER stress, impaired protein degradation pathways, altered proteostasis, and the accumulation of toxic protein products in the brain (393, 394)