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ArticlesVolume 363, Issue 9418p1346-1353April 24, 2004 Download Full Issue Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis Dr Andrew G Renehan, PhDa [email protected] Marcel Zwahlen, PhDc Prof Christoph Minder, PhDc Sarah T ODwyer, MDa Prof Stephen M Shalet, MDb Prof Matthias Egger, MDc,d Affiliations & NotesArticle InfoLinked Articles (1) Summary Background Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival, and are thought to be important in tumour development

Based on the BPRF metrics, which provide a conservative interpretation of the existing data, evidence for an association with other pharyngeal cancer (excluding nasopharyngeal cancers) was very strong, with alcohol use at average intake levels associated with at least a 105% increased risk (five-star rating)

Several areas warrant prioritization in future research

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