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Although there is limited published evidence explicitly documenting a stronger cultural bias in Asian populations favoring joint preservation over knee arthroplasty, these patients often have higher functional demands for deep knee flexion post-TKA (for example, squatting and kneeling) 140

For instance, GPX4 palmitoylation by ZDHHC20 enhances its stability, while APT2-mediated depalmitoylation promotes ferroptosis in colorectal cancer and metastasis models (61)

PhGs show significant hepatoprotective potential through their multi-target mechanisms, addressing critical processes such as oxidative stress, inflammation, apoptosis, and fibrosis