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Kalynchuk, [email protected] This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

For researchers conducting long-term studies or those with needle aversion, these practical considerations may outweigh the bioavailability difference

combination data is nonexistent Safety first Overlapping side effect profiles create legitimate concerns about additive adverse events Patience pays Phase 3 trials for both compounds are ongoing

miRNAs are small, mature, non-coding RNA molecules (about 22 nucleotides long) that can affect the processing of target mRNAs at the post-transcriptional level by translational inhibition or promoting mRNA degradation (281)