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In another in vitro and in vivo study, Nrf2/HO-1 was also demonstrated to play an important inhibitory role in the pro-fibrotic pathway activated by TGF-1, which was verified by oligo-fucoidan in NRK-52E cells and kidney tissues of C57BL/6 mice [151]

(2004) Proceedings of the National Academy of Sciences (PNAS) , 101(39): 1490714912 Foundational study identifying the EPO/-common receptor heteromer (IRR) as the mediator of EPOs tissue-protective effects, distinct from the EPOR homodimer responsible for erythropoiesis

This breakdown or dyshomeostasis of biometals whereby antioxidant protection is overwhelmed in favor of elevated concentration of metals leads to a state of neurotoxicity with damaging interaction to proteins, lipid peroxidation, and DNA, all evidence of increased oxidative stress in the AD affected brain (Jomova et al., 2010

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