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Researches indicate that the risk of all-cause mortality in individuals with T2DM is 1.8 times higher than in those without T2DM, and the medical costs associated with T2DM are reported to be 2.3 times greater than those of individuals without T2DM [1, 2]

Global changes in interleukin-6-dependent gene expression patterns in mouse livers after partial hepatectomy

Bioorg Med Chem Lett 20 , 260265, (2010)

It is worth noting that thiostreptozotocin promotes ferroptosis by downregulating GPX4 mRNA and GPX levels mainly by decreasing intracellular STAT3 and p-STAT3 expression rather than affecting SLC7A11 protein expression [140]