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Why the Manufacturing Route Is Recombinant, Not Synthetic Solid-phase peptide synthesis (SPPS), the dominant route for research-grade peptides since Merrifield's 1963 demonstration of the method [3], becomes progressively inefficient as chain length grows: small yield losses at each coupling step compound across many residues, and full-length recovery falls

Levels of reduced and oxidized forms of GSH (GSSG) were also quantified in plasma, PBMCs, and RBCs isolated from T2DM subjects at pre- and post- L-GSH/or placebo supplementation

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Sci Rep 7:17886