The highest abundance functional categories were associated with metabolism, which primarily consisted of carbohydrate, amino acid, energy, and nucleotide metabolism (Fig
Mait establishes realistic timelines based on individual assessment and treatment goals
In addition, exercise activates the AMPK signaling pathway, accelerating fatty acid -oxidation, effectively reducing hepatic lipid accumulation, and improving blood lipid profiles, as evidenced by increased HDL levels and decreased LDL levels (Bekheit et al., 2025)
Disclosures: Eduardo Vilar-Gomez: Nothing to Disclose, Katherine Yates: Nothing to Disclose, David Kleiner: Nothing to Disclose, Cynthia Behling: Pacific Rim Pathology Lab: Employee, Novo Nordisk: Consultant, Pathology Institute: Consultant, Oscar Cummings: Nothing to Disclose, Laura Wilson: Nothing to Disclose, Tiebing Liang: Nothing to Disclose, Chaowapong Jarasvaraparn: Nothing to Disclose, Rohit Loomba: Eli Lilly and Company: Consultant, Jeffrey Schwimmer: Intercept: Grant to institution, Seraphina: Grant/Research Support, Intercept: Grant/Research Support, Merck: Consultant, Arun Sanyal: Genfit, Akarna, Tiziana, Durect, Inversago, Hemoshear, North: Stock - publicly traded company, Astra Zeneca ( 60K), Boston Pharmaceutical ( 18) enrolled between 2016-2023 in the TARGET-NASH longitudinal cohort includes patients receiving routine clinical care in the US meeting criteria for non-cirrhotic MASH, MASH with compensated cirrhosis or MASH with decompensated cirrhosis, based on TARGET-NASH definitions, were included in this analysis
