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Figure 3 3.3 Longitudinal in vivo biodistribution and tumor targeting capacity of anti-uPAR bimodal sdAbs Finally, the biodistribution and tumor-targeting capacity of uPAR15-GEM-[ 99m Tc]Tc(CO) 3 -IRDye800CW were evaluated in vivo in HT-29 tumor-bearing mice and compared to the non-targeting R3b23-based compound

It's a highly individual response

By acquiring dependence on a limited number of critical signaling pathways for survival, cancer cells may become sensitive to inhibition of these pathways, which has been the basis for targeted therapy (15)