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This process mainly relies on the active targeting mechanism: by modifying specific ligands on the surface of the nanoparticles, they can be recognized and internalized by target cells when flowing through the liver [178]

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Permeability study In addition to TEER measurements, Lucifer yellow (100 M, Sigma-Aldrich) dissolved in phenol red-free DMEM (Biochrom) was added to the apical compartment of the Snapwells to determine the integrity of the cellular layer

Yes, the treatment is generally safe when performed by qualified professionals in a certified clinic