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Potential Risks and Side Effects of Synthetic HGH The Endocrine Society notes several concerns with synthetic HGH therapy, particularly when used for anti-aging purposes rather than true medical deficiency: Fluid retention and edema (swelling in hands and feet) Joint pain and muscle aches Carpal tunnel syndrome Increased insulin resistance and potential diabetes risk Gynecomastia (enlarged breast tissue in men) Potential acceleration of existing cancers (though not proven to cause cancer) Suppression of natural pituitary function These side effects typically occur because synthetic HGH provides constant, unregulated hormone levels rather than the natural pulsatile (rhythmic) secretion your body is designed to produce

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[DOI] [PMC free article] [PubMed] [Google Scholar] 96.de Zevallos J.O., Hogwood A.C., Kruse K., De Guzman J., Buckley M., Weltman A.L., Allen J.D