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It's also involved in 5 : Neutralizing singlet oxygen, hydroxyl radicals, and superoxide radials Serving a cofactor for antioxidant enzymes Regenerating vitamin C and E Neutralizing free radicals produced during Phase 1 liver metabolism of toxins Transporting mercury out of cells and the brain Regulating cell proliferation and apoptosis Supporting mitochondrial function Maintaining mitochondrial DNA Aside from its antioxidant role, one of the other key functions it's involved in is detoxifying both xenobiotic and endogenous compounds 5

As show in Figure 5, Zebularine could be continuously administered to maintain the demethylated state due to its low toxicity

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Studies have found that ALDH and GSH pathways have a potential detoxification effect on toxic aldehydes by delaying the development of aging-related diseases caused by 4-HNE