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Alpha-Lipoic Acid: Biological Mechanisms and Health Benefits

Penile erection mainly depends on the activation of NO/cGMP signal pathway and the function of PDE5 is to block the decomposition of cyclic guanosine monophosphate (cGMP) ( PDE5Is are the first-line treatment for erectile dysfunction ( In addition to acting on PDE5 of cavernous smooth muscle, PDE5I also inhibits PDE5 and its isozymes in blood vessels, viscera, skeletal muscle, platelets, and other tissues, causing reactions in multiple systems

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In summary, ROS production triggers DR5 expression in the DHA-TF treated cells, making the cells more susceptible for DHER treatment