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Description

Single-cell transcriptomics and proteomics studies reveal that suppressing excessive autophagy in established obesity paradoxically improves metabolic outcomes by reducing inflammatory activation

Biol Psychiat 57(1):4448

However, inhibiting CAF autophagy effectively suppressed anti-tumor immune responses and anti-tumor efficacy in mouse models by upregulating CD274/PD-L1 levels [128, 129]