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Untreated anemia can be debilitating and may become life-threatening in severe cases

The effects of rTMS can result in long-term changes in neural connections and patterns of neuronal activation

In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

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