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Autophagy as a cell death and tumor suppressor mechanism

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It has been reported that AC inhibited the proliferation of HT29 human colon cancer cells in a dose-dependent manner with an IC 50 of approximately 50 g/mL, where it exhibited strong anti-metastatic and anti-invasive effects by inhibiting the Rac family small GTPase 1 (Rac-1), hypoxia-inducible factor-1 alpha (HIF-1), and zinc finger E-box-binding homeobox 1 (Zeb-1) pathways (Seyfi et al