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Heart, liver, kidney and brain tissues were rapidly removed and clamped frozen at liquid N 2 temperature and stored at80 C

Mechanism of action DNF-10: decreasing food intake It has been demonstrated that there is a significant impact on the modulators of short-term food intake at both the hypothalamic level (NPY) and the digestive level, resulting in a decrease in the hunger hormone ghrelin

Dosing should be individualized and titrated according to clinical response, typically starting at 30 mg three times daily and increasing in 30 mg increments every 23 days to a target range of 60120 mg per dose every 36 hours