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Frances Oldham Kelsey Pediatric Pharmacology: Chloramphenicol Death of three newborn infants in 1960 Followed administration of moderately large amounts of chloramphenicol Recommended IM dose of microcrystalline suspension was 100 to 150 mg/kg/day for children of 15 kg or less One death at dose of 220 mg/kg/day for 2.5 days One death at dose of 23o mg for 3 days Recommended oral dose of chloramphenicol palmitate suspension was 50 - 150 mg/kg/day for children of 15 kg or less One death at dose o 50 mg/kg/day for 2.7 days and 10 hr after a single inadvertent dose of 400 mg Kefauver-Harris Amendment Thalidomide: 10,000 deformities in 46 countries Chloramphenicol: Children deaths Initiated 1962 Amendment to US Food, Drug and Cosmetics Act Before marketing firms must prove safety and effectiveness for proposed use, and disclose potential side effects Pediatric pharmacology: Whats unique

Athletes cutting weight, older adults worried about sarcopenia, and anyone prioritizing body composition over scale weight may find special value in adding Sermorelin to support lean tissue retention

No need to mix with juice or water

Confirming previous observations, another study using the EPIC array found no DMP in a large cohort [70]