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Unlike metformin, which has documented effects on ileal B12 uptake, GLP-1 and GIP receptor agonists do not directly affect the intrinsic factor-B12 complex or terminal ileum absorption

Sequential treatment allows providers to assess tolerance and efficacy at each step before introducing complexity

Prior studies have used the cell cycle proteins p16, p21, p53 and Rb to differentiate between dividing and non-dividing cells, but the non-dividing cells can include senescent cells and quiescent cells 36