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Importantly, the percentage change in MDA levels was significantly greater in the NAC group compared to the control group on day 7, highlighting the more pronounced effect of NAC in reducing oxidative stress ( 21.81 vs 9.94, p = 0.049) (Table 2)

Because bup/nx has very high opioid receptor affinity, it can precipitate withdrawal in patients who are opioid-intoxicated or in very early withdrawal