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507 Loss-of-function mutations in CBL are also linked to autoreactive inflammatory disorders, further implicating the UPS in MS pathogenesis

4 Transaminase Upregulation and Targeting Amino Acid Synthesis for Cancer Therapy Another means of inhibiting glutaminolysis is to target alanine transaminase through L-cycloserine or aspartate transaminase through the inhibitor amino oxyacetate, which could almost completely halt the growth of breast cancer in xenograft mice [117, 118]

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We found that the amount of AngIV in mouse tissue increased after the administration of Dihexa compared to that in the WT group