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Irradiation-induced T-MP can be taken up by tumor cells and TAMs, resulting in increased ferroptosis, PD-L1 expression, and M1 phenotype TAMs (96)

Other patients also experienced clinical improvements, including a 6 year old boy with severe diabetes, ketosis (accumulation of ketones, a term first used by the German chemist Leopold Gmelin - figure 5), heavy glycosuria and malnutrition (de Levia, Brugus, de Leiva-Prez)

Several suicide switches [G] have been described, whereby administration of an otherwise inert drug causes controlled apoptosis of the infused CAR T cell product 115

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