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However, it is well documented that submucosal and intramural UFs that alter the uterine cavity have a negative impact on endometrial receptivity, implantation, and live birth rates ( FIGURE 4 Effect of Uterine Fibroids on Endometrial Receptivity and Implantation Implantation is a process that involves a highly regulated and synchronous development of the embryo and the endometrium to make it amenable to implantation, a process that occurs between 7 and 10 days after ovulation and is known as the window of implantation (WOI) ( Critical Factors in Endometrial Implantation The family of homeobox genes comprises 39 HOX transcription factors that are fundamental to the proper development of the female reproductive tract and to endometrial development during the menstrual cycle ( HOXA10 and HOXA11 , which are expressed in the endometrium throughout the proliferative phase and reach a peak in the mid-secretory phase under the influence of progesterone (Taylor et al., 1998, 1999)
Overall, ndufs2 -/- zebrafish recapitulate severe CI deficiency, complex metabolic pathophysiology, and relevant LSS neuromuscular and survival phenotypes, enabling future translational studies of therapeutic candidates
