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Annu Rev Psychol 70:703718 Tousoulis D, Guzik T, Padro T, Duncker DJ, De Luca G et al (2022) Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation

At the gene level it modulates over 4,000 human genes, including 47 directly involved in DNA repair

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More recently, another pathway came into play with the discovery of dihydronicotinamide riboside (NRH) as a new NAD + precursor [15,48]