amantadine and l-carnitine treatment of chronic fatigue syndrome New Strategies for Rehabilitation Pharmacological in Multiple Sclerosis Myalgic encephalomyelitis / Chronic Fatigue – What is the evidence for

doi: 10.5173/ceju.2013.01.art19 5 DuttaSSenguptaPSamrotAV

A., Pehar M., Helke K

Abstract Many local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart disease and stroke, cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 19 (COVID-19), involve both, (1) oxidative stress with excessive production of reactive oxygen species (ROS) that lower glutathione (GSH) levels, and (2) inflammation

Altered circadian rhythm leads to increased oxidative stress resulting in the nuclear translocation of Nrf2, where it binds to the ARE initiating the transcription of several cytoprotective genes