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Adv Clin Exp Med (2017) 26(9):14315

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Plants that Support Target Gene Expression (Step 7) Phytotherapeutic agents that are involved in the final process of instructing the gene to express itself should rightfully include all the plants that first helped promote heterodimerization because without the xanthohumol from Humulus lupulus, guggulsterones from Commiphora mukul, carnosol from Rosmarinus officinalis, and withanolides from Withania somnifera there would be no RXR/TR heterodimers

Nevertheless, genetic variation only explains a minor part of interindividual variability, suggesting regulation by nuclear receptors, PAPS-cofactor availability and inhibition by various drugs and environmental compounds could be major determinants of variability in SULT activity 15