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First, oxaliplatin both increased the expression of the M2 acetylcholine receptors and decreased acetylcholine levels in the posterior insula whereas either activating the M2 receptor or restoring acetylcholine levels specifically in the posterior insula reversed CIPN symptoms (Kanat et al., 2013)

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Role of RNS in protein misfolding and Lewy Body deposition Alpha-Synuclein protofibril formation in PD Many causal aSyn mutations have been identified (A30P, A53T, E46K, G51D, duplication, and triplication) in PD patients

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health