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Although a plethora of macrophage phenotypes has been identified by the advent of single cell biology - amongst others resident macrophages, TNF + pro-inflammatory macrophages, IL1 + pro-inflammatory macrophages, Trem2 + macrophages, lipid-associated Trem2 hi-perilipin + macrophages, and IL10 + TNFAIP3 + macrophages (de Winther et al., 2023

However, these specifically targeted elements within the design that benefit from the implementation of Predictive Maintenance technologies, are ultimately only individual actors within the much broader integrated system

Gln67 of TNF- also donates an h-bond to the carbonyl of VNAR-C4 Thr89, forming a backbone-backbone interaction common among VNARs 24

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