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HIF-1 activation leads to the transcription of genes involved in angiogenesis, glycolysis, and cell survival, facilitating tumor growth and adaptation to hypoxic conditions [108]

Freitas Gouveia M, Trueb RM (2017) Unsuccessful Tteatment of alopecia areata with simvastatin/ezetimibe: experience in 12 patients

Additionally, NAD + is required for fatty acid metabolism during -oxidation, glutaminolysis generating -ketoglutarate, mitochondrial shuttling of metabolites, and lactic acid fermentation 35