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POPs are mainly excreted through conjugation with GSH and this mechanism is extremely important for the health status, since exposure to POPs has been associated to diabetes, cardiovascular diseases and many other chronic diseases (1, 13)

The cleaved RNA fragments are copied into first-strand cDNA using SuperScript II reverse transcriptase (Invitrogen, 18064014) and random primers

[28] found that NNMT knockdown significantly reduced the body weight, fat mass, and insulin level of female mice fed a Western diet (fat 47% kcal, carbohydrate 34% kcal), as did NNMT knockout

10.1371/journal.pone.0097774 PLoS One 58 RouillonA.BarbeyR.PattonE