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B) Presence of possible confounding variables: The study did not report on potential confounding variables, such as demographic or environmental factors, that could influence the association between the GSTM1 and GSTT1 genes and addiction to opioids and methamphetamine

(e) patient will not undergo any changes to current medical and psychosocial intervention(s) during planned treatment period

Conversely, other studies report decreased ACSL4 levels in the hippocampus of MCAO rats after reperfusion, coinciding with elevated thrombin activity

These observed sex-dependent differences have been attributed to sex-dependent metabolic alterations such as the estrogen-dependent synthesis of phosphatidylcholines 88,89,90,91