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Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles

These findings offer epidemiological support for lifestyle-based interventions that target both movement and micronutrient sufficiency to delay age-related physiological decline ( In contrast, the DO-HEALTH randomized clinical trial, which enrolled over 2,150 older adults across Europe (mean age of 75 years), tested a combination of vitamin D3 supplementation (2000 IU/day), omega-3 fatty acids (1 g/day), and a strength-training program over a three-year period