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We have developed a novel, stable formulation of reduced glutathione for oral delivery (sold as ReadiSorb liposomal reduced glutathione by YES, LLC of Palo Alto, Calif.) and report that liposomal encapsulation markedly enhances the cellular bioavailability of reduced glutathione, meaning the novel, stable formulation is both storable for long periods and survives oral administration, and as a result, intracellular glutathione is enhanced and achieves results not achievable by non-intravenous administration of either plain glutathione (in any form) or non-liposomal reduced glutathione (which is normally largely oxidized in the gastrointestinal tract)

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Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ: Activation of Paneth cell -defensins in mouse small intestine

Figure 1 Cats were categorized into subgroups based on the presence of CKD-related complications, including proteinuria, hypertension, anemia, and iron supplementation