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Adverse reactions reported in these studies listed by system organ class included 1 : Cardiac disorders: ventricular extrasystoles Investigations: electrocardiogram repolarization abnormality, heart rate increased Respiratory, thoracic, and mediastinal disorders: pleural effusion Smoke-Inhalation Studies A prospective, uncontrolled, open-label study spanning almost 7 years was carried out in 69 subjects who had been exposed to smoke inhalation from fires

Long-term safety unknowns Chronic use effects: Most protocols last weeks to months

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