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Loss of KDM6A in mice suppresses the PI3K-AKT-mTOR signaling pathway, leading to reprogramming into glucose and lipid metabolism in HCC [26]

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Although regional FFQs do exist, the predefined list of food groups and items in FFQs are likely developed according to Western or European diets, limiting their adaptability and extrapolability to other countries

In addition, in vivo studies and patient-derived xenografts could validate the clinical significance of these ncRNA-mediated mechanisms, potentially identifying biomarkers for predicting DOX response and new therapeutic targets to overcome resistance