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Clinical score was based on age when thalassemia symptoms appeared, time of diagnosis, time of first blood transfusion, pre-transfusion hemoglobin concentration, frequency of transfusions, and enlargement of spleen

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Recent studies demonstrated that NINJ1 deficiency failed to confer protection against ferroptotic cell death induced by RSL3 and ML162, GPX4 inhibitors, in RAW 264.7 cells and murine embryonic fibroblasts (MEFs) [33, 34]

Because it lacks GH receptor agonism and does not elevate IGF-1 meaningfully, concerns about carpal tunnel, fluid retention, and glucose dysregulation that accompany full hGH therapy are less applicable