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doi: 10.1111/jgh.15796 196 ZhangH.ZhouZ

These findings open new avenues for therapeutic intervention, such as targeting mitochondrial quality control, mtDNA release, or cGAS-STING signaling to mitigate neuroinflammation and slow disease progression

Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Ehrlich Sachs S, et al

The enzyme l-GalDH generates cytosolic NADH, which has to be re-oxidized to allow the availability of NAD + and therefore sustain the reaction ( Figure 3 )