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Despite extensive research and considerable efforts for developing targeted therapies, it is still an alarming condition with a poor prognosis and high mortality

Our study provides compelling evidence that the DDIT4/PGC-1 axis is a critical novel pathway through which AMSCs restore mitochondrial function and confer protection against APAP-induced hepatotoxicity

This process further increases Snail levels and drives EnMT

In FGF control tumors, combination therapy by simultaneous blocking of VEGF and PDGFR signaling increased the necrotic area in tumors (Supplementary Fig