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These effects were associated with increased nuclear factor erythroid 2-related factor 2 (Nrf2) gene expression, suggesting involvement of both antioxidant and anti-inflammatory mechanisms ( TLR4 signaling has been implicated in inflammation-induced immunopathogenesis during viral infection (Verlaet et al., 2019)

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Several mechanisms are involved in the upregulation of xCT expression by amino acid deprivation, xenobiotics and, particularly, oxidative stress (165, 166)

BPC-157 is under FDA advisory review in July 2026, and FDA staff documents recommend caution because human safety and effectiveness data are limited