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As such, while in vitro investigations provide important mechanistic insights, their results cannot be directly generalised to pharmacological or clinical implications without rigorous validation

Consistency is key with both natural and professional methods, as lasting results depend on regular care and maintenance

These include systemic medications such as methotrexate, cyclosporine, retinoids, 6-thioguanine, mycophenolate mofetil, troglitazone, and new biologic agents like adalimumab, alefacept, efalizumab, etanercept, and infliximab, as well as topical therapies like steroids, vitamin D analogues, psoralen, 5-aminolevulinic acid, salicylates, fumaric acid esters, anthralins (dithranol), tacrolimus, and retinoids, such as tazarotene

The methanol extract of Salvia miltiorrhiza Bunge, known as tanshinone, has been shown to upregulate phosphatase and tensin homologue (PTEN) protein expression and inhibit the phosphorylation of AKT at Thr 308 and Ser 473