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The question then arises: What is the explanation for this unique apparent regulation of Se-GSH-Px by organic selenium? Regulation of the GSH-Px system The glutathione (GSH) system, comprising oxidized and reduced GSH and the two enzymes GSH peroxidase and GSH reductase, is closely related to the metabolism of two amino acids, cysteine (Cys) and methionine (Met) (Figure 3) via the key intermediary metabolite, homocysteine