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The metabolic activity of the gut microbial flora on hormones, which controls enterohepatic recycling, iodine uptake/deterioration, and levothyroxine bioavailability, is connected to the release of TSH (Cayres et al

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Therefore, alternative hepatocyte models based on cancer cell lines, such as human hepatoblastoma HepG2 cells, have been developed to provide more accessible and scalable systems for in vitro studies