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References 09738086 Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB

The risk of severe GI events is increased by the presence of the following factors: history of peptic ulcer disease or GI bleed, smoking, alcohol usage, concomitant usage of anticoagulants, or oral corticosteroids, older age, and poor general health status

It provides a more stable, sustained presence of the peptide in the bloodstream rather than a rapid peak and fall, potentially allowing for a more prolonged therapeutic window

Both adenosylcobalamin and hydroxycobalamin are generally considered highly safe and well-tolerated, as they are water-soluble vitamins and excess amounts are easily excreted in the urine