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Glutathione S-transferase pi (GST-pi) is up-regulated by oxidative stress through NF-B 53

In doing so, we highlight interesting activity in pathways such as pyruvate metabolism, glycolysis, carnitine shuttle (mitochondria) pathway, bile acid synthesis (BAS), chondroitin/heparan biosynthesis and heparan sulphate degradation as possible significant drivers of M1/M2 polarization in lungs

Crit Rev Toxicol 14(4):309380 Fujioka K, Shibamoto T (2006) Determination of toxic carbonyl compounds in cigarette smoke

Mice were intermittently handled, with body weights and food intake (hopper weights) measured 2-3 times per week