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Dose conversions from humans to rats were made to establish the conditions of 5 and 20 mg/kg/day to represent typical serum concentrations for recreational cocaine abusers and beneath the concentrations for acute cocaine poisoning overdose 44,45

50 These results not only underscore the importance of CPTIA in modulating AR in prostate cancer, 50 but also indicate that there exist mutual feedback regulations between AR and CPTI (Figure 3)

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