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Regulatory pathways are also becoming clearer

Higher pain perception and lack of recovery from neuropathic pain in females: a behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice

They especially lack mitochondrial ISC-containing subunits of respiratory chain complexes I, II and III and aconitase activities

The Wnt/-catenin pathway enhances regulatory effects of Nurr1, including TH promoter activation, indicating that Nurr1 is a key determinant of VTA DA neurotransmitter identity by controlling genes involved in DA synthesis, vesicular packaging, axonal transport, and reuptake (Jankovic et al., 2005)