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Although we cannot rule out a contribution of glycolysis to this ATP increase and did not directly assess the activity of other complexes, we observed increased 5FU sensitivity with inhibitors of ETC complexes IIV, genetic ablation of CI and CIV, and sensitizer genes from CRISPR screening covering additional complexes (CIII and CV)

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The reasons for this precaution are many and hinge on ensuring your safety and optimising surgical outcomes

Theoretical concerns include growth factor-related effects in individuals with existing malignancies and immune modulation in vulnerable populations