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We demonstrate that the cancer-related truncated variants ASXL1 1-645 and ASXL1 1-591 retain BRD4 binding function, with ASXL1 1-645 showing an enhanced ability to recruit BRD4 to ASXL1-occupied promoter regions

Oehlers SH, Cronan MR, Scott NR, Thomas MI, Okuda KS, Walton EM, Beerman RW, Crosier PS, Tobin DM

Subsequently, it was found that co-inactivation of DHODH and mitochondrial GPX4 led to mitochondrial lipid peroxidation and that BQR treatment significantly increased the intracellular CoQ10/CoQH2 ratio [103], suggesting that DHODH inhibits mitochondrial lipid peroxidation by reducing CoQ10 to CoQH2 in concert with mitochondrial GPX4

(10) Studies have documented that IGF-1 signaling promotes fibroblast proliferation, collagen synthesis, and angiogenesisall critical components of wound healing