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In the face of restricted glucose availability, immune cells exhibit a profound dependence on the uptake and catabolism of glutamine as a means to sustain the TCA cycle, a pivotal process crucial for their ongoing viability and functionality [114,115,116]

N-acetyl cysteine (NAC) is hydrophilic

After assessing the literature, we divided medications into one of three groups: medications that should be avoided in individuals with G6PD deficiency, medications that were considered unsafe by at least one source, but according to our review can probably be given safely in normal therapeutic dosages to individuals with G6PD deficiency as evidence does not contravene their use, and medications where no evidence at all was found to contravene their use in G6PD-deficient patients

Crucially, in a mouse model of collagen-induced arthritis, targeted silencing of MCT4 within the articular synovium significantly attenuated disease severity by inducing apoptosis in RASFs, offering direct proof-of-concept for this approach [122]