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Following the recommended daily allowance for calcium, using supplements only when needed

Experimental models indicate that these contacts facilitate the initiation of Ca 2+ -dependent exocytosis, support efficient ATP production, and limit the excessive accumulation of Ca 2+ in the cytosol, thereby preserving cell viability ( Under physiological conditions, calcium signals generated by the ER in response to stimulation of acetylcholine (ACh) or CCK receptors are transmitted to mitochondria via a sequence of protein structures: IP 3 R (inositol trisphosphate receptors) channels on the ER, the chaperone GRP75 (75-kDa glucose-regulated protein), the channel VDAC1 (voltage-dependent anion channel 1) on the outer mitochondrial membrane (OMM), and the mitochondrial calcium uniporter (MCU) on the inner mitochondrial membrane (IMM)

Due to the antioxidative and antimutagenic role of GPXs, there is a considerable interest in their therapeutic use as antioxidants